PRINCIPLE Trial – aiming to find COVID-19 treatments for older people

We are taking part in the national PRINCIPLE clinical trial. The trial aims to find low-risk medicines that can help people with COVID-19 symptoms get better quickly and stop them needing to go to hospital.

To take part, you need to be:

1. Experiencing symptoms that are likely to be caused by a COVID-19 infection, for fewer than 15 days:

  • A new continuous cough – this means coughing a lot for more than an hour, or 3 or more coughing episodes in 24 hours (if you usually have a cough, it may be worse than usual)
  • and/or a high temperature – this means you feel hot to touch on your chest or back (you do not need to take your temperature).

2. You also need to be aged 50 to 64, with at least one of the following conditions:

weakened immune system due to a serious illness or medication (e.g. chemotherapy)​,

heart disease or high blood pressure​,

asthma or lung disease​,

diabetes not treated with insulin,

liver disease,

stroke or neurological problem​,

OR you can take part if you have symptoms of COVID-19 and are aged 65 and over.

Participation is entirely voluntary. Once you have read more information, if you are interested in taking part, we ask you to complete a short online form to see if you are eligible.

You can also join the trial online, even if you are not currently registered with our practice. For full details, visit: